![]() Methods: Using computational protein structure prediction the trimeric component of a two‐component self‐assembling protein nanoparticle (I53‐50NP) was redesigned to allow SOSIP trimer fusion. Here, we present the design and characterization of two‐component protein nanoparticles displaying twenty SOSIP trimers. Displaying antigens in a multivalent fashion on nanoparticles or virus‐like particles is a well‐established strategy to increase their immunogenicity. However, these neutralizing antibody responses are relatively weak, short‐lived, and narrow in specificity. Sanders 1ġAcademic Medical Center, Amsterdam, Netherlands, 2University of Washington, Seattle, United States, 3The Scripps Research Institute, San Diego, United States, 4Weill Medical College of Cornell University, New York, United States, 5University of Southampton, Biological Sciences, Southampton, United Kingdomīackground: The development of soluble native‐like HIV‐1 envelope trimers (SOSIP trimers) has enabled the induction of neutralizing antibodies against neutralization‐resistant (Tier‐2) primary HIV‐1 strains in several animal models. ![]() ![]() Two‐component self‐assembling nanoparticle vaccines that present multiple HIV‐1 envelope trimers
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